CLDN1 monoclonal antibody (M01), clone 1C5-D9
产品名称： CLDN1 monoclonal antibody (M01), clone 1C5-D9
英文名称： CLDN1 monoclonal antibody (M01), clone 1C5-D9
产品编号： H00009076-M01
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against a full length recombinant CLDN1.
- Immunogen:
- CLDN1 (AAH12471.1, 1 a.a. ~ 211 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (48.95 KDa) .
- MSDS:
Download
- Publication Reference
- 1.
- HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells.
Florentin J, Aouar B, Dental C, Thumann C, Firaguay G, Gondois-Rey F, Soumelis V, Baumert TF, Nunes JA, Olive D, Hirsch I, Stranska R.Blood. 2012 Nov 29;120(23):4544-51. doi: 10.1182/blood-2012-02-413286. Epub 2012 Oct 10.
- 2.
- Permissiveness of human hepatoma cell lines for HCV infection.
Sainz B Jr, Barretto N, Yu X, Corcoran P, Uprichard SL.Virol J. 2012 Jan 24;9(1):30. [Epub ahead of print]
- 3.
- Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier.
Fletcher NF, Wilson GK, Murray J, Hu K, Lewis A, Reynolds GM, Stamataki Z, Meredith LW, Rowe IA, Luo G, Lopez-Ramirez MA, Baumert TF, Weksler B, Couraud PO, Kim KS, Romero IA, Jopling C, Morgello S, Balfe P, McKeating JA.Gastroenterology. 2011 Nov 30.
- 4.
- Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression.
Kanki Y, Kohro T, Jiang S, Tsutsumi S, Mimura I, Suehiro J, Wada Y, Ohta Y, Ihara S, Iwanari H, Naito M, Hamakubo T, Aburatani H, Kodama T, Minami T.EMBO J. 2011 Jun 10;30(13):2582-95. doi: 10.1038/emboj.2011.173.
- 5.
- Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo.
Shaykhiev R, Otaki F, Bonsu P, Dang DT, Teater M, Strulovici-Barel Y, Salit J, Harvey BG, Crystal RG.Cell Mol Life Sci. 2010 Sep 6. [Epub ahead of print]
- 6.
- Tumor-Associated Calcium Signal Transducer 2 Is Required for the Proper Subcellular Localization of Claudin 1 and 7. Implications in the Pathogenesis of Gelatinous Drop-Like Corneal Dystrophy.
Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S.Am J Pathol. 2010 Jul 22. [Epub ahead of print]
- 7.
- Novel HCV replication mouse model using human hepatocellular carcinoma xenografts.
Guevin C, Lamarre A, Labonte P.Antiviral Res. 2009 Oct;84(1):14-22. Epub 2009 Jul 19.
- 8.
- Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection.
Sainz B Jr, TenCate V, Uprichard SL.Virol J. 2009 Jul 15;6:103.
- 9.
- Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells.
Stamataki Z, Shannon-Lowe C, Shaw J, Mutimer D, Rickinson AB, Gordon J, Adams DH, Balfe P, McKeating JA.Blood. 2009 Jan 15;113(3):585-93. Epub 2008 Oct 6.
- 10.
- Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity.
Farquhar MJ, Harris HJ, Diskar M, Jones S, Mee CJ, Nielsen SU, Brimacombe CL, Molina S, Toms GL, Maurel P, Howl J, Herberg FW, van Ijzendoorn SC, Balfe P, McKeating JA.J Virol. 2008 Sep;82(17):8797-811. Epub 2008 Jun 25.
- 11.
- CD81 and Claudin 1 Coreceptor Association: Role in Hepatitis C Virus Entry.
Harris HJ, Farquhar MJ, Mee CJ, Davis C, Reynolds GM, Jennings A, Hu K, Yuan F, Deng H, Hubscher SG, Han JH, Balfe P, McKeating JA.J Virol. 2008 May;82(10):5007-20. Epub 2008 Mar 12.
- 12.
- Effect of cell polarization on hepatitis C virus viral entry.
Mee CJ, Grove J, Harris HJ, Hu K, Balfe P, McKeating JA.J Virol. 2008 Jan;82(1):461-70. Epub 2007 Oct 24.
- Applications
- Western Blot (Cell lysate)
- CLDN1 monoclonal antibody (M01), clone 1C5-D9. Western Blot analysis of CLDN1 expression in PRC/PRF/5.
- Protocol Download
- Western Blot (Cell lysate)
- CLDN1 monoclonal antibody (M01), clone 1C5-D9. Western Blot analysis of CLDN1 expression in A-431 ( Cat # L015V1 ).
- Protocol Download
- Western Blot (Transfected lysate)
- Western Blot analysis of CLDN1 expression in transfected 293T cell line by CLDN1 monoclonal antibody (M01), clone 1C5-D9.
Lane 1: CLDN1 transfected lysate(23 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to CLDN1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to CLDN1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 5 ug/ml]
- Protocol Download
- Immunoprecipitation
- Immunoprecipitation of CLDN1 transfected lysate using anti-CLDN1 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with CLDN1 MaxPab rabbit polyclonal antibody.
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged CLDN1 is approximately 0.03ng/ml as a capture antibody.
- Protocol Download
- Application Image
- Western Blot (Cell lysate)
- enlarge
- Western Blot (Cell lysate)
- enlarge
- Western Blot (Transfected lysate)
- enlarge
- Western Blot (Recombinant protein)
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunoprecipitation
- enlarge
- Sandwich ELISA (Recombinant protein)
- enlarge
- ELISA
- Entrez GeneID:
- 9076
- GeneBank Accession#:
- BC012471
- Protein Accession#:
- AAH12471.1
- Gene Name:
- CLDN1
- Gene Alias:
- CLD1,ILVASC,SEMP1
- Gene Description:
- claudin 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq
- Other Designations:
- senescence-associated epithelial membrane protein 1