AXIN2 polyclonal antibody
产品名称： AXIN2 polyclonal antibody
英文名称： AXIN2 polyclonal antibody
产品编号： PAB19407
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AXIN2.
- Immunogen:
- A synthetic peptide corresponding to 20 amino acids near C-terminus of human AXIN2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- AXIN2 antibody is predicted to not cross-react with AXIN2. At least four isoforms of AXIN2 are known to exist; this antibody will recognize all four.
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 8313
- Protein Accession#:
- AAF22799
- Gene Name:
- AXIN2
- Gene Alias:
- AXIL,DKFZp781B0869,MGC10366,MGC126582
- Gene Description:
- axin 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq
- Other Designations:
- conductin
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma, Squamous Cell
- Cleft Lip
- Cleft Palate
- Colorectal Neoplasms
- Dental Enamel Hypoplasia
- Depressive Disorder, Major
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hirschsprung Disease
- Lung Neoplasms
- Neoplasm Invasiveness
- Neoplasms, Second Primary
- Osteoporosis, Postmenopausal
- Ovarian cancer
- Ovarian Neoplasms