VISA polyclonal antibody
产品名称： VISA polyclonal antibody
英文名称： VISA polyclonal antibody
产品编号： PAB13251
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of VISA.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 13 amino acids of human VISA.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Antiviral innate immunity pathways.
Seth RB, Sun L, Chen ZJ.Cell Res. 2006 Feb;16(2):141-7.
- 2.
- Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J.Nature. 2005 Oct 20;437(7062):1167-72. Epub 2005 Sep 21.
- 3.
- VISA is an adapter protein required for virus-triggered IFN-beta signaling.
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB.Mol Cell. 2005 Sep 16;19(6):727-40.
- Entrez GeneID:
- 57506
- Protein Accession#:
- NP_065797
- Gene Name:
- VISA
- Gene Alias:
- CARDIF,DKFZp547C224,DKFZp666M015,FLJ27482,FLJ35386,FLJ38051,FLJ41962,IPS-1,IPS1,KIAA1271,MAVS,MGC3260
- Gene Description:
- virus-induced signaling adapter
- Omim ID:
- 609676
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM
- Other Designations:
- CARD adapter inducing interferon-beta,OTTHUMP00000030141,interferon-beta promoter stimulator protein 1,mitochondrial anti-viral signaling protein,virus-induced signaling adapter variant 1b,virus-induced signaling adaptor variant 1a
- Related Disease